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Alexandre Chenal Selected Research

Adenylate Cyclase Toxin

1/2020Functional and structural consequences of epithelial cell invasion by Bordetella pertussis adenylate cyclase toxin.
1/2019The Adenylate Cyclase (CyaA) Toxin from Bordetella pertussis Has No Detectable Phospholipase A (PLA) Activity In Vitro.
1/2019Post-translational acylation controls the folding and functions of the CyaA RTX toxin.
11/2018Translocation and calmodulin-activation of the adenylate cyclase toxin (CyaA) of Bordetella pertussis.
7/2018Calcium-dependent disorder-to-order transitions are central to the secretion and folding of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough.
1/2018Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy.
11/2017Membrane-Active Properties of an Amphitropic Peptide from the CyaA Toxin Translocation Region.
10/2017Stability, structural and functional properties of a monomeric, calcium-loaded adenylate cyclase toxin, CyaA, from Bordetella pertussis.
8/2017Exposure to Bordetella pertussis adenylate cyclase toxin affects integrin-mediated adhesion and mechanics in alveolar epithelial cells.
10/2014Calcium, acylation, and molecular confinement favor folding of Bordetella pertussis adenylate cyclase CyaA toxin into a monomeric and cytotoxic form.
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Alexandre Chenal Research Topics

Disease

16Whooping Cough (Pertussis)
01/2019 - 06/2006
4Dehydration (Water Stress)
11/2017 - 01/2009
2Rupture
09/2017 - 08/2017
1Neuroblastoma
10/2020
1Neurodegenerative Diseases (Neurodegenerative Disease)
10/2020
1Stroke (Strokes)
10/2020
1Cough
01/2020
1Infections
11/2017
1Acquired Immunodeficiency Syndrome (AIDS)
11/2016
1Neuroendocrine Tumors (Neuroendocrine Tumor)
09/2016
1Carcinoma (Carcinomatosis)
06/2016
1Septic Shock (Toxic Shock Syndrome)
03/2016
1Necrosis
01/2010
1Pathologic Processes
09/2009
1Anthrax
05/2009
1Bacillary Dysentery (Shigellosis)
03/2007
1Seasonal Allergic Rhinitis (Hay Fever)
03/2005
1Neoplasms (Cancer)
01/2003

Drug/Important Bio-Agent (IBA)

16Adenylate Cyclase ToxinIBA
01/2020 - 06/2006
8Virulence Factors (Pathogenicity Factors)IBA
01/2019 - 06/2006
8Proteins (Proteins, Gene)FDA Link
11/2017 - 01/2003
6Adenylyl Cyclases (Adenylyl Cyclase)IBA
01/2019 - 01/2010
3CalciumIBA
07/2018 - 01/2009
2Biological ProductsIBA
09/2009 - 03/2005
2VaccinesIBA
03/2005 - 01/2003
1MetalsIBA
10/2020
1Amyloid (Amyloid Fibrils)IBA
10/2020
1AntibodiesIBA
10/2020
1Glycerol (Glycerine)FDA LinkGeneric
11/2017
1proteoliposomesIBA
09/2017
1Bond Force dental cementIBA
08/2017
1A-factor (Streptomyces)IBA
08/2017
1Peptides (Polypeptides)IBA
11/2016
1Octreotide (Sandostatin)FDA LinkGeneric
09/2016
1Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
09/2016
1pasireotideIBA
09/2016
1Clostridium sordellii lethal toxin LTIBA
03/2016
1Amino AcidsFDA Link
10/2014
1Cytotoxins (Cytolysins)IBA
03/2010
1Calmodulin (Calcium-Dependent Activator Protein)IBA
01/2010
1Caspase 3 (Caspase-3)IBA
01/2010
1Propidium (Propidium Iodide)IBA
01/2010
1PerforinIBA
05/2009
1CholesterolIBA
05/2009
1Recombinant ProteinsIBA
03/2005
1CytokinesIBA
01/2003
1Interleukin-2 (IL2)IBA
01/2003

Therapy/Procedure

1Therapeutics
10/2020